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MLH1 Mouse mAb

Heterodimerizes with PMS2 to form MutL alpha,a component of the post-replicative DNA mismatch repair system (MMR).DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch,then MutL alpha is recruited to the heteroduplex.Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2.

Alternative Name(s)

DNA mismatch repair protein Mlh1; MutL protein homolog 1; COCA2;

Application

WB

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UNIprot

P40692

clonality

Monoclonal

reactivity

Human

Research area

Epigenetics And Nuclear Signaling

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

MLH1 Mouse mAb

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